{"id":5881,"date":"2024-09-10T12:05:52","date_gmt":"2024-09-10T04:05:52","guid":{"rendered":"https:\/\/lsjylc.com\/?p=5881"},"modified":"2024-09-10T12:08:53","modified_gmt":"2024-09-10T04:08:53","slug":"2024-wclc-garsorasib%ef%bc%88d-1553%ef%bc%89%e6%b2%bb%e7%96%97kras-g12c%e7%aa%81%e5%8f%98%e8%82%ba%e7%99%8c%e7%9a%842%e6%9c%9f%e7%a0%94%e7%a9%b6%e6%9c%80%e6%96%b0%e8%bf%9b%e5%b1%95","status":"publish","type":"post","link":"https:\/\/lsjylc.com\/2024\/09\/10\/2024-wclc-garsorasib%ef%bc%88d-1553%ef%bc%89%e6%b2%bb%e7%96%97kras-g12c%e7%aa%81%e5%8f%98%e8%82%ba%e7%99%8c%e7%9a%842%e6%9c%9f%e7%a0%94%e7%a9%b6%e6%9c%80%e6%96%b0%e8%bf%9b%e5%b1%95\/","title":{"rendered":"2024 WCLC | Garsorasib\uff08D-1553\uff09\u6cbb\u7597KRAS G12C\u7a81\u53d8\u80ba\u764c\u76842\u671f\u7814\u7a76\u6700\u65b0\u8fdb\u5c55"},"content":{"rendered":"\t\t
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2024\u4e16\u754c\u80ba\u764c\u5927\u4f1a\uff08WCLC\uff09\u4e8e\u5f53\u5730\u65f6\u95f49\u67087\u65e5\u81f310\u65e5\u5728\u7f8e\u56fd\u5723\u5730\u4e9a\u54e5\u53ec\u5f00\u3002\u5728\u6b64\u6b21\u5927\u4f1a\u4e0a\uff0c\u4e0a\u6d77\u5e02\u80f8\u79d1\u533b\u9662\u7684\u674e\u5b50\u660e<\/i><\/span>\u6559\u6388\u4ee5\u53e3\u5934\u62a5\u544a\uff08oral presentation\uff09\u5f62\u5f0f\u516c\u5e03\u4e86garsorasib\u6cbb\u7597KRAS G12C\u7a81\u53d8\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c<\/i><\/span>\uff08NSCLC\uff09\u76842\u671f\u7814\u7a76\u6700\u65b0\u8fdb\u5c55\uff1a\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u4e3a52%\uff0c\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u4e3a88.6%\uff0c\u4e2d\u4f4d\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\uff08DOR\uff09\u4e3a12.5\u4e2a\u6708\uff0c\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u4e3a9.1\u4e2a\u6708\uff0c\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\uff08OS\uff09\u4e3a14.1\u4e2a\u6708<\/strong>\uff0c\u8fdb\u4e00\u6b65\u80af\u5b9a\u4e86garsorasib\u5728\u8be5\u60a3\u8005\u4eba\u7fa4\u4e2d\u7684\u4e34\u5e8a\u4ef7\u503c[1]<\/sup>\u3002<\/p>

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Garsorasib\uff08D-1553\uff09\u662f\u76ca\u65b9\u751f\u7269\u81ea\u4e3b\u7814\u53d1\u7684\u65b0\u578bKRAS G12C\u6291\u5236\u5242\u3002\u8fd9\u662f\u4e00\u9879\u5f00\u653e\u6807\u7b7e\u3001\u591a\u4e2d\u5fc3\u3001\u5355\u81c22\u671f\u7814\u7a76\uff08NCT05383898\uff09\uff0c\u65e8\u5728\u8bc4\u4f30garsorasib\u5728KRAS G12C\u7a81\u53d8\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u60a3\u8005\u4e2d\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u3002\u8be5\u98792\u671f\u7814\u7a76\u6700\u65e9\u53d1\u8868\u57282024\u7f8e\u56fd\u764c\u75c7\u7814\u7a76\u534f\u4f1a\uff08AACR\uff09\u5e74\u4f1a[2]<\/sup>\uff0c\u4ee5\u53ca\u300a\u67f3\u53f6\u5200-\u547c\u5438\u75c5\u5b66\u300b\uff08The Lancet Respiratory Medicine\uff09[3]<\/sup>\u3002\u76f8\u6bd4\u6b64\u524d\u5df2\u53d1\u8868\u7684\u6570\u636e\uff08\u622a\u6b62\u65e5\u671f\uff1a2023\u5e7411\u670817\u65e5\uff09\uff0c\u672c\u6b21\u66f4\u65b0\u7684\u6570\u636e\uff08\u622a\u6b62\u65e5\u671f\uff1a2024\u5e745\u670817\u65e5\uff09\uff0c\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u5ef6\u957f\u81f312.3\u4e2a\u6708\u3002<\/p>

\u5165\u7ec4\u60a3\u8005\u63a5\u53d7garsorasib 600 mg BID\u6cbb\u7597\uff0c21\u5929\u4e3a\u4e00\u4e2a\u6cbb\u7597\u5468\u671f\u3002\u4e3b\u8981\u5165\u9009\u6807\u51c6\u6709\uff1aKRAS G12C\u7a81\u53d8\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f6c\u79fb\u6027\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\uff1b\u65e2\u5f80\u7ecf\u6297PD-(L)1\u6cbb\u7597\u548c\u542b\u94c2\u5316\u7597\u540e\u75be\u75c5\u8fdb\u5c55\u6216\u56e0\u6bd2\u6027\u4e0d\u8010\u53d7\u4e0a\u8ff0\u6cbb\u7597\uff1b\u5e76\u6839\u636eRECIST v1.1\u6807\u51c6\u5177\u6709\u53ef\u6d4b\u91cf\u75c5\u7076\u3002\u4e3b\u8981\u7ec8\u70b9\u662f\u7531\u76f2\u6001\u72ec\u7acb\u5ba1\u67e5\u59d4\u5458\u4f1a\uff08IRC\uff09\u6839\u636e RECIST v1.1 \u8bc4\u4f30\u7684ORR\u3002\u6b21\u8981\u7ec8\u70b9\u5305\u62ecDOR\u3001DCR\u3001\u81f3\u7f13\u89e3\u65f6\u95f4\uff08TTR\uff09\u3001PFS\u3001OS\u548c\u5b89\u5168\u6027\u3002<\/p>

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\u53c2\u8003\u8d44\u6599\uff1a<\/p>

<\/section>

[1]\u00a0\u539f\u6587\u94fe\u63a5\uff1ahttps:\/\/cattendee.abstractsonline.com\/meeting\/20598\/Session\/153<\/p>

[2]\u00a0\u539f\u6587\u94fe\u63a5\uff1ahttps:\/\/doi.org\/10.1158\/1538-7445.AM2024-CT246<\/p>

[3]\u00a0\u539f\u6587\u94fe\u63a5\uff1ahttps:\/\/www.thelancet.com\/journals\/lanres\/article\/PIIS2213-2600(24)00110-3\/abstract<\/p><\/section>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

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