{"id":5802,"date":"2023-10-21T21:52:42","date_gmt":"2023-10-21T13:52:42","guid":{"rendered":"https:\/\/lsjylc.com\/?p=5802"},"modified":"2024-09-04T13:53:38","modified_gmt":"2024-09-04T05:53:38","slug":"2023-esmo-garsorasib%e8%a5%bf%e5%a6%a5%e6%98%94%e5%8d%95%e6%8a%97%e6%b2%bb%e7%96%97kras-g12c%e7%aa%81%e5%8f%98%e7%bb%93%e7%9b%b4%e8%82%a0%e7%99%8c%ef%bc%8c%e7%96%97%e6%95%88%e6%98%be%e8%91%97","status":"publish","type":"post","link":"https:\/\/lsjylc.com\/2023\/10\/21\/2023-esmo-garsorasib%e8%a5%bf%e5%a6%a5%e6%98%94%e5%8d%95%e6%8a%97%e6%b2%bb%e7%96%97kras-g12c%e7%aa%81%e5%8f%98%e7%bb%93%e7%9b%b4%e8%82%a0%e7%99%8c%ef%bc%8c%e7%96%97%e6%95%88%e6%98%be%e8%91%97\/","title":{"rendered":"2023 ESMO | Garsorasib+\u897f\u59a5\u6614\u5355\u6297\u6cbb\u7597KRAS G12C\u7a81\u53d8\u7ed3\u76f4\u80a0\u764c\uff0c\u7597\u6548\u663e\u8457\uff01"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"5802\" class=\"elementor elementor-5802\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-89d1b39 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"89d1b39\" data-element_type=\"section\">\n\t\t\t\t\t\t<div   id="c0zinl5lcz"    class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-81e8984\" data-id=\"81e8984\" data-element_type=\"column\">\n\t\t\t<div   id="c0zinl5lcz"    class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-802deba elementor-widget elementor-widget-text-editor\" data-id=\"802deba\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div   id="c0zinl5lcz"    class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>2023\u6b27\u6d32\u80bf\u7624\u5b66\u4f1a\uff08ESMO\uff09\u5e74\u4f1a\u4e8e\u5f53\u5730\u65f6\u95f410\u670820\u65e5\u81f324\u65e5\u5728\u897f\u73ed\u7259\u9a6c\u5fb7\u91cc\u53ec\u5f00\u3002\u76ca\u65b9\u751f\u7269\u81ea\u4e3b\u7814\u53d1\u7684KRAS G12C\u6291\u5236\u5242Garsorasib\uff08D-1553\uff09\u8054\u5408\u897f\u59a5\u6614\u5355\u6297\uff08Cetuximab\uff09\u5728KRAS G12C\u7a81\u53d8\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u60a3\u8005\u4e2d\u7684\u4e00\u9879II\u671f\u7814\u7a76\u7ed3\u679c\u6210\u529f\u5165\u9009\u672c\u6b21\u5927\u4f1a\uff0c\u7531\u4e2d\u5c71\u5927\u5b66\u80bf\u7624\u9632\u6cbb\u4e2d\u5fc3\u5f90\u745e\u534e\u6559\u6388\u8fdb\u884c\u53e3\u5934\u62a5\u544a\u3002<\/p><section><strong>\u6570\u636e\u663e\u793a\uff1aGarsorasib\u8054\u5408\u897f\u59a5\u6614\u5355\u6297\u5728\u65e2\u5f80\u7ecf\u6cbb\u7684KRAS G12C\u7a81\u53d8\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u4e2d\u5ba2\u89c2\u7f13\u89e3\u7387\uff08ORR\uff09\u8fbe45%\uff0c\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08mPFS\uff09\u4e3a7.6\u4e2a\u6708\u3002<\/strong><\/section><section><img fetchpriority=\"high\" decoding=\"async\" class=\"aligncenter wp-image-5804 size-full\" src=\"https:\/\/lsjylc.com\/wp-content\/uploads\/2024\/09\/640-4.png\" alt=\"\" width=\"865\" height=\"479\" srcset=\"https:\/\/lsjylc.com\/wp-content\/uploads\/2024\/09\/640-4.png 865w, https:\/\/lsjylc.com\/wp-content\/uploads\/2024\/09\/640-4-300x166.png 300w, https:\/\/lsjylc.com\/wp-content\/uploads\/2024\/09\/640-4-768x425.png 768w\" sizes=\"(max-width: 865px) 100vw, 865px\" \/><\/section><section><p>Garsorasib\u662f\u7531\u76ca\u65b9\u751f\u7269\u81ea\u4e3b\u7814\u53d1\u7684\u4e00\u6b3e\u65b0\u578b\u3001\u9ad8\u6548\u7684KRAS G12C\u9009\u62e9\u6027\u6291\u5236\u5242\u3002\u5728KRAS G12C\u7a81\u53d8\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u4e2d\uff0cGarsorasib\u5355\u836f\u6cbb\u7597\u8010\u53d7\u6027\u826f\u597d\uff0c\u5c55\u73b0\u51fa\u4e86\u826f\u597d\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u8be5\u90e8\u5206\u7814\u7a76\u7ed3\u679c\u5df2\u4e8e2023\u5e74\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a\u5e74\u4f1a\uff08ASCO 2023\uff09\u4e0a\u4ee5\u4f1a\u8bae\u58c1\u62a5\u5f62\u5f0f\u516c\u5e03[1]\u3002<\/p><section>\u5728\u6b64\u6b21ESMO\u5927\u4f1a\u4e0a\u76ca\u65b9\u751f\u7269\u516c\u5e03\u4e86Garsorasib\u8054\u5408\u897f\u59a5\u6614\u5355\u6297\uff08\u4e00\u79cd\u9776\u5411EGFR\u7684\u6297\u4f53\uff09\u5728KRAS G12C\u7a81\u53d8\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u4e2d\u7684\u6700\u65b0\u7814\u7a76\u6570\u636e\u3002<\/section><section>\u622a\u81f32023\u5e748\u670810\u65e5\uff0c\u5165\u7ec440\u4f8bKRAS G12C\u7a81\u53d8CRC\u60a3\u8005\u3002\u4e2d\u4f4d\u968f\u8bbf\u65f6\u95f4\u4e3a9.1\u4e2a\u6708\u3002\u60a3\u8005\u4e2d\u4f4d\u5e74\u9f8454\u5c81\uff1b37.5%\u4e3a\u5973\u6027\uff1bECOG PS \u8bc4\u5206\u4e3a0\u548c1\u7684\u60a3\u8005\u5206\u522b\u536027.5%\u548c72.5% \uff1b80.0%\u7684\u60a3\u8005\u65e2\u5f80\u63a5\u53d7\u8fc7\u22652\u7ebf\u7cfb\u7edf\u6027\u6cbb\u7597\u3002<\/section><section><p>\u622a\u81f32023\u5e748\u670810\u65e5\uff0c\u572840\u4f8b\u60a3\u8005\u4e2d\uff0c\u670918\u4f8b\u60a3\u8005\u90e8\u5206\u7f13\u89e3\uff08PR\uff09\uff0c20\u4f8b\u60a3\u8005\u75be\u75c5\u7a33\u5b9a\uff08SD\uff09\uff0cORR\u4e3a45.0% (18\/40)\uff0c\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u4e3a95.0% (38\/40)\u3002\u572892.5%\u7684\u60a3\u8005\u4e2d\u89c2\u5bdf\u5230\u9776\u75c5\u7076\u7f29\u5c0f\u3002<\/p><p>\u622a\u81f3\u6570\u636e\u622a\u6b62\u65e5\uff0c21\u4f8b\u60a3\u8005\u4ecd\u5728\u7ec4\u6cbb\u7597\uff08\u5176\u4e2d12\u4f8b\u4ecd\u5904\u4e8e\u7f13\u89e3\u72b6\u6001\uff09\uff0c\u4e2d\u4f4d\u8fbe\u7f13\u89e3\u65f6\u95f4\u4e3a5.9\u5468\uff08\u8303\u56f4\uff1a5.0\uff0c24.1\uff09\uff0c\u4e2d\u4f4d\u7f13\u89e3\u6301\u7eed\u65f6\u95f4\uff08DOR\uff09\u4e3a8.6\u4e2a\u6708\uff0895%CI\uff1a4.9\uff0cNA\uff09\u3002<\/p><section>mPFS\u4e3a7.6\u4e2a\u6708\uff0895% CI\uff1a5.5\uff0c10.0\uff09\u3002\u4e2d\u4f4d\u603b\u751f\u5b58\u671f\uff08OS\uff09\u5c1a\u672a\u8fbe\u5230\uff0c\u9884\u8ba1\u76849\u4e2a\u6708OS\u7387\u4e3a82.4%\uff0895%CI\uff1a62.0\uff0c92.5\uff09\u3002<\/section><section><img decoding=\"async\" class=\"aligncenter wp-image-5805 size-full\" src=\"https:\/\/lsjylc.com\/wp-content\/uploads\/2024\/09\/640-5.png\" alt=\"\" width=\"865\" height=\"486\" srcset=\"https:\/\/lsjylc.com\/wp-content\/uploads\/2024\/09\/640-5.png 865w, https:\/\/lsjylc.com\/wp-content\/uploads\/2024\/09\/640-5-300x169.png 300w, https:\/\/lsjylc.com\/wp-content\/uploads\/2024\/09\/640-5-768x432.png 768w\" sizes=\"(max-width: 865px) 100vw, 865px\" \/><\/section><section>\u572840\u4f8bKRAS G12C\u7a81\u53d8CRC\u60a3\u8005\u4e2d\uff0c\u5927\u591a\u6570\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\uff08TRAE\uff09\u4e3a\u8f7b\u5ea6\u6216\u4e2d\u5ea6\u3002\u6700\u5e38\u89c1\uff08\u53d1\u751f\u7387\u2265 10%\uff09\u7684TRAE\u6709\u76ae\u75b9\u3001\u5929\u95e8\u51ac\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176\u5347\u9ad8\u3001\u4e19\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176\u5347\u9ad8\u3001\u7532\u6c9f\u708e\u3001\u8840\u80c6\u7ea2\u7d20\u5347\u9ad8\u3001\u76ae\u80a4\u88c2\u3001\u4fbf\u79d8\u3001\u75e4\u75ae\u6837\u76ae\u708e\u3001\u8179\u6cfb\u3001\u76ae\u80a4\u5e72\u71e5\u548c\u6076\u5fc3\u30023\u7ea7TRAE\u5305\u62ec\u76ae\u75b9\uff0c\u75e4\u75ae\u6837\u76ae\u708e\uff0c\u4f4e\u9541\u8840\u75c7\u548c\u7619\u75d2\u6027\u76ae\u75b9\u3002\u65e04\/5\u7ea7TRAE\u3002Garsorasib\u4e0e\u897f\u59a5\u6614\u5355\u6297\u8054\u5408\u6cbb\u7597\u7684\u5b89\u5168\u6027\u8010\u53d7\u6027\u826f\u597d\uff0c\u4e0e\u5355\u72ec\u7528\u836f\u5728\u5b89\u5168\u6027\u65b9\u9762\u65e0\u663e\u8457\u5dee\u5f02\u3002<\/section><section><img decoding=\"async\" class=\"aligncenter wp-image-5806 size-full\" src=\"https:\/\/lsjylc.com\/wp-content\/uploads\/2024\/09\/640-6.png\" alt=\"\" width=\"859\" height=\"486\" srcset=\"https:\/\/lsjylc.com\/wp-content\/uploads\/2024\/09\/640-6.png 859w, https:\/\/lsjylc.com\/wp-content\/uploads\/2024\/09\/640-6-300x170.png 300w, https:\/\/lsjylc.com\/wp-content\/uploads\/2024\/09\/640-6-768x435.png 768w\" sizes=\"(max-width: 859px) 100vw, 859px\" \/><\/section><section><section>Garsorasib\u8054\u5408\u897f\u59a5\u6614\u5355\u6297\u5728\u65e2\u5f80\u7ecf\u6cbb\u7684KRAS G12C\u7a81\u53d8\u7ed3\u76f4\u80a0\u764c\u60a3\u8005\u4e2d\u5c55\u73b0\u4e86\uff1a<\/section><section data-role=\"list\"><section data-role=\"list\"><section>1. \u53ef\u559c\u7684\u521d\u6b65\u7597\u6548\uff0c\u4e0eGarsorasib\u5355\u836f\u6216\u6807\u51c6\u6cbb\u7597\uff08SoC\uff09\u76f8\u6bd4\uff0c\u7597\u6548\u6709\u8f83\u5927\u63d0\u5347\u3002<\/section><\/section><section data-role=\"list\"><ul class=\"list-paddingleft-1\"><li><section>ORR\uff1a45% vs. 20%\uff08Garsorasib\u5355\u836f\uff09vs. ~2% \uff083\u7ebf\u60a3\u8005\u7684\u6807\u51c6\u6cbb\u7597\uff09\uff1b<\/section><\/li><li><section>mPFS\uff1a7.6\u4e2a\u6708 vs. 5.4\u4e2a\u6708\uff08Garsorasib\u5355\u836f\uff09vs. ~2\u4e2a\u6708\uff083\u7ebf\u60a3\u8005\u7684\u6807\u51c6\u6cbb\u7597\uff09\u3002<\/section><\/li><\/ul><\/section><section>2.\u00a0\u53ef\u63a7\u7684\u5b89\u5168\u6027\u7279\u5f81\u3002<\/section><ul class=\"list-paddingleft-1\"><li><section>\u4e0e\u5355\u72ec\u7528\u836f\u7684\u5b89\u5168\u6027\u7279\u5f81\u76f8\u4f3c\uff1b<\/section><\/li><li><section>\u8054\u5408\u7528\u836f\u672a\u89c2\u5bdf\u5230\u5176\u4ed6\u65b0\u589e\u5b89\u5168\u6027\u4fe1\u53f7\u3002<\/section><\/li><\/ul><\/section><\/section><\/section><\/section>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>2023\u6b27\u6d32\u80bf\u7624\u5b66\u4f1a\uff08ESMO\uff09\u5e74\u4f1a\u4e8e\u5f53\u5730\u65f6\u95f410\u670820\u65e5\u81f324\u65e5\u5728\u897f\u73ed\u7259\u9a6c\u5fb7\u91cc\u53ec\u5f00\u3002\u76ca\u65b9\u751f\u7269\u81ea\u4e3b\u7814\u53d1\u7684KRA&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-5802","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/lsjylc.com\/wp-json\/wp\/v2\/posts\/5802"}],"collection":[{"href":"https:\/\/lsjylc.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lsjylc.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lsjylc.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/lsjylc.com\/wp-json\/wp\/v2\/comments?post=5802"}],"version-history":[{"count":8,"href":"https:\/\/lsjylc.com\/wp-json\/wp\/v2\/posts\/5802\/revisions"}],"predecessor-version":[{"id":5813,"href":"https:\/\/lsjylc.com\/wp-json\/wp\/v2\/posts\/5802\/revisions\/5813"}],"wp:attachment":[{"href":"https:\/\/lsjylc.com\/wp-json\/wp\/v2\/media?parent=5802"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lsjylc.com\/wp-json\/wp\/v2\/categories?post=5802"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lsjylc.com\/wp-json\/wp\/v2\/tags?post=5802"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}