{"id":5774,"date":"2023-05-18T16:32:30","date_gmt":"2023-05-18T08:32:30","guid":{"rendered":"https:\/\/lsjylc.com\/?p=5774"},"modified":"2024-09-04T14:28:58","modified_gmt":"2024-09-04T06:28:58","slug":"%e7%9b%8a%e6%96%b9%e7%94%9f%e7%89%a9kras-g12c%e6%8a%91%e5%88%b6%e5%89%82d-1553%e4%b8%b4%e5%ba%8a%e5%89%8d%e7%a0%94%e7%a9%b6%e6%95%b0%e6%8d%ae%e5%8f%91%e8%a1%a8%e4%ba%8ecancer-science","status":"publish","type":"post","link":"https:\/\/lsjylc.com\/2023\/05\/18\/%e7%9b%8a%e6%96%b9%e7%94%9f%e7%89%a9kras-g12c%e6%8a%91%e5%88%b6%e5%89%82d-1553%e4%b8%b4%e5%ba%8a%e5%89%8d%e7%a0%94%e7%a9%b6%e6%95%b0%e6%8d%ae%e5%8f%91%e8%a1%a8%e4%ba%8ecancer-science\/","title":{"rendered":"\u76ca\u65b9\u751f\u7269KRAS G12C\u6291\u5236\u5242D-1553\u4e34\u5e8a\u524d\u7814\u7a76\u6570\u636e\u53d1\u8868\u4e8eCancer Science"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"5774\" class=\"elementor elementor-5774\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-732a0a0 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"732a0a0\" data-element_type=\"section\">\n\t\t\t\t\t\t<div   id="c0zinl5lcz"    class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-bc4ce56\" data-id=\"bc4ce56\" data-element_type=\"column\">\n\t\t\t<div   id="c0zinl5lcz"    class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-cbf9043 elementor-widget elementor-widget-text-editor\" data-id=\"cbf9043\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div   id="c0zinl5lcz"    class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><strong>5\u67089\u65e5\uff0c\u76ca\u65b9\u751f\u7269\u81ea\u4e3b\u7814\u53d1\u7684KRAS<sup>G12C<\/sup>\u6291\u5236\u5242D-1553\u4e34\u5e8a\u524d\u7814\u7a76\u6570\u636e\u5728\u56fd\u9645\u671f\u520a\u300aCancer Science\u300b\u4e0a\u53d1\u8868\u3002\u6807\u9898\u4e3a\u201c<\/strong><strong>D-1553: A Novel KRAS<sup>G12C<\/sup>\u00a0Inhibitor with Potent and Selective Cellular and\u00a0<em>In Vivo<\/em>\u00a0Antitumor Activity<\/strong><strong>\u201d\u3002<\/strong>\u8be5\u9879\u4e34\u5e8a\u524d\u7814\u7a76\u7ed3\u679c\u4e3aD-1553\u7684\u4e34\u5e8a\u5f00\u53d1\u63d0\u4f9b\u4e86\u5f3a\u6709\u529b\u7684\u652f\u6301\u3002\u76ee\u524d\uff0cD-1553\u6b63\u5728\u56fd\u5185\u5916\u5f00\u5c55\u591a\u9879\u4e34\u5e8a\u7814\u7a76\uff0c\u7528\u4e8e\u6cbb\u7597\u5e26\u6709KRAS<sup>G12C<\/sup>\u7a81\u53d8\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NSCLC\uff09\u3001\u7ed3\u76f4\u80a0\u764c\uff08CRC\uff09\u7b49\u591a\u79cd\u764c\u75c7\u3002<\/p><p><img fetchpriority=\"high\" decoding=\"async\" class=\"aligncenter wp-image-5777 size-full\" src=\"https:\/\/lsjylc.com\/wp-content\/uploads\/2024\/09\/640.png\" alt=\"\" width=\"865\" height=\"393\" srcset=\"https:\/\/lsjylc.com\/wp-content\/uploads\/2024\/09\/640.png 865w, https:\/\/lsjylc.com\/wp-content\/uploads\/2024\/09\/640-300x136.png 300w, https:\/\/lsjylc.com\/wp-content\/uploads\/2024\/09\/640-768x349.png 768w\" sizes=\"(max-width: 865px) 100vw, 865px\" \/><\/p><p>D-1553\u662f\u4e00\u79cd\u5f3a\u6548\u9009\u62e9\u6027KRAS<sup>G12C<\/sup>\u6291\u5236\u5242\u3002\u76f8\u6bd4\u5176\u4ed6KRAS<sup>G12C<\/sup>\u6291\u5236\u5242\uff08sotorasib, adagrasib\uff09\uff0cD-1553\u5bf9GDP\u7ed3\u5408\u72b6\u6001\u7684KRAS<sup>G12C<\/sup>\u7a81\u53d8\u86cb\u767d\u5177\u6709\u66f4\u5f3a\u7684\u7ed3\u5408\u80fd\u529b\uff0c\u4ece\u800c\u4f7fKRAS<sup>G12C<\/sup>\u9501\u5b9a\u5728\u975e\u6d3b\u5316\u72b6\u6001\uff0c\u5e76\u963b\u65adKRAS\u901a\u8def\u7684\u4fe1\u53f7\u8f6c\u5bfc\u3002<\/p><p>\u5728\u7ec6\u80de\u5b9e\u9a8c\u4e2d\uff0cD-1553\u53ef\u9009\u62e9\u6027\u6291\u5236KRAS<sup>G12C<\/sup>\u7a81\u53d8\u7ec6\u80de\u7cfb\u7684\u7ec6\u80de\u751f\u957f\uff08\u80ba\u6ce1\u7ec6\u80de\u764cSW1573\u7ec6\u80de\u7cfb\u9664\u5916\uff09\uff0c\u4e14\u5728\u591a\u6570\u7ec6\u80de\u4e2d\u8be5\u6291\u5236\u4f5c\u7528\u6bd4sot orasib\u548cadagrasib\u7565\u5f3a\u3002<\/p><p>\u5728KRAS<sup>G12C<\/sup>\u7a81\u53d8\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08NCI-H358\uff09\u3001\u80f0\u817a\u764c\uff08MIA PaCa-2\uff09\u3001\u7ed3\u76f4\u80a0\u764c\uff08SW837\uff09\u548c\u80ba\u817a\u764c\uff08NCI-H2122\uff09\u5f02\u79cd\u79fb\u690d\u6a21\u578b\u5c0f\u9f20\u5b9e\u9a8c\u4e2d\uff0c<strong>D-1553\u5355\u836f\u4f7f\u8377\u7624\u5c0f\u9f20\u4f53\u5185\u7684\u80bf\u7624\u4f53\u79ef\u663e\u8457\u7f29\u5c0f\uff0c\u5c55\u73b0\u51fa\u5f3a\u6548\u7684\u6297\u80bf\u7624\u4f5c\u7528<\/strong>\uff08\u89c1<strong>\u56fe<\/strong><strong>1A-D<\/strong>\uff09\uff1b\u540c\u65f6\u5728\u4e00\u7cfb\u5217\u4eba\u7c7b\u6765\u6e90\u7684\uff08KRAS<sup>G12C<\/sup>\u7a81\u53d8\u7684\u80ba\u764c\u3001\u80c3\u764c\u3001\u7ed3\u76f4\u80a0\u764c\u3001\u80f0\u817a\u764c\u3001\u5375\u5de2\u764c\u548c\u8180\u80f1\u764c\uff09\u5f02\u79cd\u79fb\u690d\u6a21\u578b\u4e2d\uff0c\u4e5f<strong>\u89c2\u5bdf\u5230D-1553\uff0860\u2009mg\/kg\uff09\u4f7f\u5c0f\u9f20\u80bf\u7624\u6d88\u9000<\/strong>\uff08\u89c1<strong>\u56fe<\/strong><strong>1E<\/strong>\uff09\uff1b\u800c\u5728KRAS<sup>G12C<\/sup>\u7a81\u53d8\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\u548c\u7ed3\u76f4\u80a0\u764c\u5f02\u79cd\u79fb\u690d\u6a21\u578b\u5c0f\u9f20\u4e2d\uff0c<strong>D-1553\u8054\u5408\u5316\u7597\u6216\u9776\u5411\u6cbb\u7597<\/strong>\uff08\u5982MEK\u6291\u5236\u5242\u66f2\u7f8e\u66ff\u5c3c\u3001SHP2\u6291\u5236\u5242RMC-4550\u3001\u6216\u5361\u94c2\uff09<strong>\u5177\u6709\u6bd4\u5355\u836f\u66f4\u5f3a\u7684\u80bf\u7624\u6291\u5236\u4f5c\u7528<\/strong>\uff08\u89c1<strong>\u56fe<\/strong><strong>2<\/strong>\uff09\u3002<\/p><p><img decoding=\"async\" class=\"wp-image-5778 size-full aligncenter\" src=\"https:\/\/lsjylc.com\/wp-content\/uploads\/2024\/09\/640-1.png\" alt=\"\" width=\"736\" height=\"938\" srcset=\"https:\/\/lsjylc.com\/wp-content\/uploads\/2024\/09\/640-1.png 736w, https:\/\/lsjylc.com\/wp-content\/uploads\/2024\/09\/640-1-235x300.png 235w\" sizes=\"(max-width: 736px) 100vw, 736px\" \/><\/p><p style=\"text-align: center;\"><strong>\u56fe<\/strong><strong>1 D-1553<\/strong><strong>\u5f3a\u6548\u6291\u5236<\/strong><strong>KRAS<sup>G12C<\/sup><\/strong><strong>\u5f02\u79cd\u79fb\u690d\u6a21\u578b\u4f53\u5185\u80bf\u7624\u751f\u957f<\/strong><\/p><p><img decoding=\"async\" class=\"wp-image-5779 size-full aligncenter\" src=\"https:\/\/lsjylc.com\/wp-content\/uploads\/2024\/09\/640-2.png\" alt=\"\" width=\"804\" height=\"692\" srcset=\"https:\/\/lsjylc.com\/wp-content\/uploads\/2024\/09\/640-2.png 804w, https:\/\/lsjylc.com\/wp-content\/uploads\/2024\/09\/640-2-300x258.png 300w, https:\/\/lsjylc.com\/wp-content\/uploads\/2024\/09\/640-2-768x661.png 768w\" sizes=\"(max-width: 804px) 100vw, 804px\" \/><\/p><p style=\"text-align: center;\"><strong>\u00a0\u56fe<\/strong><strong>2 D-1553<\/strong><strong>\u8054\u5408\u5316\u7597\u6216\u9776\u5411\u836f\u7269\u5728<\/strong><strong>KRAS<sup>G12C<\/sup><\/strong><strong>\u7a81\u53d8\u7684\u7ec6\u80de\u7cfb\u5f02\u79cd\u79fb\u690d\u6a21\u578b\u4e2d\u7684\u6297\u80bf\u7624\u4f5c\u7528<\/strong><\/p><p><strong>D-1553\u662f\u4e00\u79cd\u5f3a\u6548\u7684\u3001\u9009\u62e9\u6027KRAS<sup>G12C<\/sup>\u6291\u5236\u5242\uff0c\u5728\u4f53\u5916\u548c\u4f53\u5185\u7684\u4e34\u5e8a\u524d\u7814\u7a76\u4e2d\u5747\u663e\u793a\u51fa\u5bf9\u80bf\u7624\u751f\u957f\u7684\u6291\u5236\u4f5c\u7528\uff0c\u4e3a\u5176\u4e34\u5e8a\u5f00\u53d1\u63d0\u4f9b\u4e86\u8bc1\u636e\u652f\u6301\u3002<\/strong>\u76ee\u524d\uff0c\u4e00\u9879\u5728KRAS<sup>G12C<\/sup>\u7a81\u53d8\u7684\u665a\u671f\u5b9e\u4f53\u7624\u60a3\u8005\u4e2d\u8bc4\u4ef7D-1553\u6709\u6548\u6027\u7684\u4e34\u5e8aII\u671f\u8bd5\u9a8c\u6b63\u5728\u8fdb\u884c\u4e2d\uff08NCT04585035\uff09\u3002<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>5\u67089\u65e5\uff0c\u76ca\u65b9\u751f\u7269\u81ea\u4e3b\u7814\u53d1\u7684KRASG12C\u6291\u5236\u5242D-1553\u4e34\u5e8a\u524d\u7814\u7a76\u6570\u636e\u5728\u56fd\u9645\u671f\u520a\u300aCancer Scie&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-5774","post","type-post","status-publish","format-standard","hentry"],"_links":{"self":[{"href":"https:\/\/lsjylc.com\/wp-json\/wp\/v2\/posts\/5774"}],"collection":[{"href":"https:\/\/lsjylc.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lsjylc.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lsjylc.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/lsjylc.com\/wp-json\/wp\/v2\/comments?post=5774"}],"version-history":[{"count":5,"href":"https:\/\/lsjylc.com\/wp-json\/wp\/v2\/posts\/5774\/revisions"}],"predecessor-version":[{"id":5785,"href":"https:\/\/lsjylc.com\/wp-json\/wp\/v2\/posts\/5774\/revisions\/5785"}],"wp:attachment":[{"href":"https:\/\/lsjylc.com\/wp-json\/wp\/v2\/media?parent=5774"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lsjylc.com\/wp-json\/wp\/v2\/categories?post=5774"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lsjylc.com\/wp-json\/wp\/v2\/tags?post=5774"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}