{"id":5729,"date":"2022-11-01T14:31:11","date_gmt":"2022-11-01T06:31:11","guid":{"rendered":"https:\/\/lsjylc.com\/?p=5729"},"modified":"2024-09-04T14:28:17","modified_gmt":"2024-09-04T06:28:17","slug":"%e7%9b%8a%e6%96%b9%e7%94%9f%e7%89%a9kras-g12c%e6%8a%91%e5%88%b6%e5%89%82%e5%bc%95nature%e5%85%b3%e6%b3%a8%ef%bc%8c%e5%9b%bd%e5%86%85%e9%a6%96%e4%b8%aa%e8%87%aa%e4%b8%bb%e7%a0%94%e5%8f%91%e5%b9%b6","status":"publish","type":"post","link":"https:\/\/lsjylc.com\/2022\/11\/01\/%e7%9b%8a%e6%96%b9%e7%94%9f%e7%89%a9kras-g12c%e6%8a%91%e5%88%b6%e5%89%82%e5%bc%95nature%e5%85%b3%e6%b3%a8%ef%bc%8c%e5%9b%bd%e5%86%85%e9%a6%96%e4%b8%aa%e8%87%aa%e4%b8%bb%e7%a0%94%e5%8f%91%e5%b9%b6\/","title":{"rendered":"\u76ca\u65b9\u751f\u7269KRAS G12C\u6291\u5236\u5242\u5f15Nature\u5173\u6ce8\uff0c\u56fd\u5185\u9996\u4e2a\u81ea\u4e3b\u7814\u53d1\u5e76\u7eb3\u5165CDE\u7a81\u7834\u6027\u6cbb\u7597\u836f\u7269"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"5729\" class=\"elementor elementor-5729\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-8ac66be elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8ac66be\" data-element_type=\"section\">\n\t\t\t\t\t\t<div   id="c0zinl5lcz"    class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8054c71\" data-id=\"8054c71\" data-element_type=\"column\">\n\t\t\t<div   id="c0zinl5lcz"    class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b8f5636 elementor-widget elementor-widget-text-editor\" data-id=\"b8f5636\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div   id="c0zinl5lcz"    class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<section><strong>\u8fd1\u65e5\uff0c\u76ca\u65b9\u751f\u7269\u6ce8\u518c\u4e34\u5e8a\u8bd5\u9a8c\u836f\u7269D-1553\u4f5c\u4e3a\u5168\u7403\u9886\u5148\u7684KRAS G12C\u6291\u5236\u5242\u88abNature\u6742\u5fd7\u65b0\u95fb\u7efc\u8ff0\u63d0<\/strong><strong>\u53ca<\/strong>\u3002\u8be5\u7efc\u8ff0\u63d0\u5230\u201c\u5df2\u6709\u6570\u5341\u9879\u9488\u5bf9KRAS\u86cb\u767d\u7684\u4e34\u5e8a\u8bd5\u9a8c\u5728\u7f8e\u56fd\u7684\u6ce8\u518c\u5e93clinicaltrials.gov\u4e2d\u6ce8\u518c\u201d\uff0c\u5728\u8fd9\u4e9bKRAS\u6291\u5236\u5242\u4e2d\uff0c\u76ca\u65b9\u751f\u7269\u6240\u7814\u53d1\u7684KRAS G12C\u6291\u5236\u5242D-1553\u540d\u5217\u5176\u4e2d\u3002<\/section><p><img fetchpriority=\"high\" decoding=\"async\" class=\"aligncenter wp-image-5731 size-full\" src=\"https:\/\/lsjylc.com\/wp-content\/uploads\/2023\/05\/D-1553.jpg\" alt=\"\" width=\"1068\" height=\"301\" srcset=\"https:\/\/lsjylc.com\/wp-content\/uploads\/2023\/05\/D-1553.jpg 1068w, https:\/\/lsjylc.com\/wp-content\/uploads\/2023\/05\/D-1553-300x85.jpg 300w, https:\/\/lsjylc.com\/wp-content\/uploads\/2023\/05\/D-1553-1024x289.jpg 1024w, https:\/\/lsjylc.com\/wp-content\/uploads\/2023\/05\/D-1553-768x216.jpg 768w\" sizes=\"(max-width: 1068px) 100vw, 1068px\" \/><\/p><p>\u6ce8\uff1a\u6587\u4e2d\u5217\u51fa\u7684KRAS\u6291\u5236\u5242\u76f8\u5173\u7684\u4e34\u5e8a\u8bd5\u9a8c<\/p><p>\u8be5\u7efc\u8ff0\u7531\u5728\u4f26\u6566\u7684\u8d44\u6df1\u8bb0\u8005Heidi Ledford\u64b0\u5199\uff0c\u53d1\u8868\u5728\u6743\u5a01\u671f\u520aNature\u6742\u5fd7\u4e0a\u3002\u6587\u4e2d\u4ee5\u9996\u6b3e\u7f8e\u56fd\u98df\u54c1\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7684\u6cbb\u7597KRAS\u7a81\u53d8\u764c\u75c7\u7684\u9776\u5411\u7597\u6cd5Sotorasib(Lumakras)\u4e3a\u5207\u5165\u70b9\uff0c\u5c55\u793a\u4e86\u4e16\u754c\u4e0aKRAS\u9776\u5411\u836f\u5f00\u53d1\u9886\u57df\u4e2d\u8ff8\u53d1\u51fa\u7684\u4ece\u672a\u6709\u8fc7\u7684\u751f\u547d\u529b\uff1a\u5305\u62ecSotorasib\u4ee5\u53ca\u53e6\u4e00\u4e2a\u9776\u5411G12C\u7684\u836f\u7269Adagrasib\u5728\u5185\uff0cKRAS\u6291\u5236\u5242\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5982\u706b\u5982\u837c\u5730\u8fdb\u884c\u3002\u6b64\u5916\uff0c\u63a2\u7d22G12C\u6291\u5236\u5242\u4e0e\u5176\u4ed6\u6297\u764c\u836f\u7269\u8054\u5408\u4f7f\u7528\uff0c\u4f8b\u5982\u4e0e\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u3001EGFR\u6291\u5236\u5242\u3001\u4ee5\u53caSHP2\u6291\u5236\u5242\u7684\u4e34\u5e8a\u524d\u548c\u4e34\u5e8a\u7814\u7a76\u6b63\u4e0d\u65ad\u63a8\u8fdb\u3002\u73b0\u5728\u6574\u4e2a\u5b66\u672f\u754c\u548c\u836f\u7269\u884c\u4e1a\u7684\u7814\u7a76\u4eba\u5458\u90fd\u5728\u52a0\u5feb\u6b65\u4f10\u8fdb\u884c\u5f00\u53d1\u6539\u8fdb\uff0c\u4e3a\u8be5\u9886\u57df\u4e0d\u65ad\u6ce8\u5165\u65b0\u6d3b\u529b\u3002<\/p><p>\u4f46\u662f\uff0c\u6587\u4e2d\u4e5f\u5bf9\u5927\u591a\u6570KRAS\u7a81\u53d8\u7684\u764c\u75c7\u60a3\u8005\u4ecd\u7f3a\u5c11\u6709\u6548\u7684\u9776\u5411\u7597\u6cd5\u3001\u4ee5\u53ca\u4e34\u5e8a\u6cbb\u7597\u4e2d\u51fa\u73b0\u7684\u8010\u836f\u8868\u793a\u4e86\u62c5\u5fe7\u3002\u5c3d\u7ba1\u8fd9\u4e9b\u90fd\u8868\u660e\u7814\u7a76\u4eba\u5458\u4ecd\u6709\u5f88\u957f\u7684\u8def\u8981\u8d70\uff0c\u4f46\u662f\u8fd9\u4e0d\u80fd\u63a9\u76d6\u76ee\u524d\u6240\u53d6\u5f97\u7684\u6210\u5c31\uff0c\u79d1\u5b66\u5bb6\u4eec\u5e0c\u671b\u8fd9\u4e9b\u9776\u5411KRAS\u7684\u65b0\u5316\u5408\u7269\u80fd\u591f\u62ef\u6551\u751f\u547d\u3002<\/p><p><strong>\u5728\u8fd9\u4e9b\u9776\u5411KRAS\u7684\u5316\u5408\u7269\u4e2d\uff0cD-1553\u662f\u7531\u76ca\u65b9\u751f\u7269\u81ea\u4e3b\u7814\u53d1\u7684KRAS G12C\u6291\u5236\u5242\uff0c\u5176I\/II\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u5728\u4e16\u754c\u8303\u56f4\u5185\u5168\u9762\u542f\u52a8\uff0c\u76ee\u524d\u5171\u6709\u56db\u9879\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u8fdb\u884c\u3002\u5728\u4e2d\u56fd\uff0cD-1553\u662f\u9996\u6b3e\u81ea\u4e3b\u7814\u53d1\u7684KRAS\u6291\u5236\u5242\uff0c\u5e76\u4e8e\u4eca\u5e74\u88abCDE\u516c\u793a\u7eb3\u5165\u7a81\u7834\u6027\u6cbb\u7597\u836f\u7269\uff0c\u5f00\u59cb\u4e86\u56fd\u5185\u9996\u4e2a\u5173\u952e\u6027\u4e34\u5e8aII\u671f\u8bd5\u9a8c\u3002<\/strong><\/p><p>\u76ca\u65b9\u751f\u7269\u5148\u540e\u4e8e\u5728\u7f8e\u56fd\u80bf\u7624\u7814\u7a76\u534f\u4f1a(AACR)\u3001\u4e16\u754c\u80ba\u764c\u5927\u4f1a(WCLC)\u4e0a\u516c\u5e03\u4e86D-1553\u4e34\u5e8a\u6570\u636e\uff0c\u65e0\u4e00\u4e0d\u5c55\u793a\u4e86D-1553\u826f\u597d\u7684\u6297\u80bf\u7624\u6d3b\u6027\u548c\u5b89\u5168\u6027\u3002\u76ee\u524d\uff0cD-1553\u663e\u793a\u51fa\u4e86\u4ee4\u4eba\u671f\u5f85\u7684\u4e34\u5e8a\u6f5c\u529b\uff0c\u800c\u76ca\u65b9\u751f\u7269\u4e5f\u5c06\u4e0d\u65ad\u63a2\u7d22D-1553\u5355\u836f\u53ca\u8054\u5408\u6cbb\u7597\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\uff0c\u81f4\u529b\u4e8e\u4e3aKRAS G12C\u7a81\u53d8\u7684\u764c\u75c7\u60a3\u8005\u5e26\u6765\u66f4\u591a\u7684\u6cbb\u7597\u9009\u62e9\u3002<\/p><p>(\u6765\u6e90\uff1a\u65b0\u89c6\u7ebf)<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>\u8fd1\u65e5\uff0c\u76ca\u65b9\u751f\u7269\u6ce8\u518c\u4e34\u5e8a\u8bd5\u9a8c\u836f\u7269D-1553\u4f5c\u4e3a\u5168\u7403\u9886\u5148\u7684KRAS G12C\u6291\u5236\u5242\u88abNature\u6742\u5fd7\u65b0\u95fb\u7efc\u8ff0\u63d0\u53ca&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-5729","post","type-post","status-publish","format-standard","hentry"],"_links":{"self":[{"href":"https:\/\/lsjylc.com\/wp-json\/wp\/v2\/posts\/5729"}],"collection":[{"href":"https:\/\/lsjylc.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lsjylc.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lsjylc.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/lsjylc.com\/wp-json\/wp\/v2\/comments?post=5729"}],"version-history":[{"count":3,"href":"https:\/\/lsjylc.com\/wp-json\/wp\/v2\/posts\/5729\/revisions"}],"predecessor-version":[{"id":5733,"href":"https:\/\/lsjylc.com\/wp-json\/wp\/v2\/posts\/5729\/revisions\/5733"}],"wp:attachment":[{"href":"https:\/\/lsjylc.com\/wp-json\/wp\/v2\/media?parent=5729"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lsjylc.com\/wp-json\/wp\/v2\/categories?post=5729"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lsjylc.com\/wp-json\/wp\/v2\/tags?post=5729"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}