{"id":5039,"date":"2022-04-11T14:57:51","date_gmt":"2022-04-11T06:57:51","guid":{"rendered":"https:\/\/lsjylc.com\/?p=5039"},"modified":"2022-11-02T15:22:35","modified_gmt":"2022-11-02T07:22:35","slug":"%e7%9b%8a%e6%96%b9%e7%94%9f%e7%89%a9kras-g12c%e6%8a%91%e5%88%b6%e5%89%82d-1553%e5%9c%a8%e4%b8%80%e6%9c%9f%e4%b8%b4%e5%ba%8a%e8%af%95%e9%aa%8c%e4%b8%ad%e5%8f%96%e5%be%97%e7%a7%af%e6%9e%81%e6%88%90","status":"publish","type":"post","link":"https:\/\/lsjylc.com\/2022\/04\/11\/%e7%9b%8a%e6%96%b9%e7%94%9f%e7%89%a9kras-g12c%e6%8a%91%e5%88%b6%e5%89%82d-1553%e5%9c%a8%e4%b8%80%e6%9c%9f%e4%b8%b4%e5%ba%8a%e8%af%95%e9%aa%8c%e4%b8%ad%e5%8f%96%e5%be%97%e7%a7%af%e6%9e%81%e6%88%90\/","title":{"rendered":"\u76ca\u65b9\u751f\u7269KRAS G12C\u6291\u5236\u5242D-1553\u5728\u4e00\u671f\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u53d6\u5f97\u79ef\u6781\u6210\u679c"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"5039\" class=\"elementor elementor-5039\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6fa3904 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6fa3904\" data-element_type=\"section\">\n\t\t\t\t\t\t<div   id="c0zinl5lcz"    class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-0dd211f\" data-id=\"0dd211f\" data-element_type=\"column\">\n\t\t\t<div   id="c0zinl5lcz"    class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9c9f15f elementor-widget elementor-widget-text-editor\" data-id=\"9c9f15f\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div   id="c0zinl5lcz"    class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p><span lang=\"ZH-CN\">\u4e0a\u6d77<\/span>2022<span lang=\"ZH-CN\">\u5e74<\/span>4<span lang=\"ZH-CN\">\u6708<\/span>11<span lang=\"ZH-CN\">\u65e5<\/span> \/<span lang=\"ZH-CN\">\u7f8e\u901a\u793e<\/span>\/ &#8212; <span lang=\"ZH-CN\">\u76ca\u65b9\u751f\u7269\uff0c\u4e00\u5bb6\u4f4d\u4e8e\u4e0a\u6d77\u5f20\u6c5f\u7684\u4e34\u5e8a\u9636\u6bb5\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u8fd1\u65e5\u9996\u6b21\u516c\u5e03\u4e86\u5176\u53e3\u670d<\/span>KRAS G12C<span lang=\"ZH-CN\">\u6291\u5236\u5242\u5728\u764c\u75c7\u60a3\u8005\u4e2d\u7684\u4e34\u5e8a\u6570\u636e\u3002\u8fd9\u4e9b\u6570\u636e\u5728<\/span>4<span lang=\"ZH-CN\">\u6708<\/span>8<span lang=\"ZH-CN\">\u65e5\u81f3<\/span>13<span lang=\"ZH-CN\">\u65e5\u5728\u7f8e\u56fd\u65b0\u5965\u5c14\u826f\u4e3e\u884c\u7684\u7f8e\u56fd\u80bf\u7624\u7814\u7a76\u534f\u4f1a\uff08<\/span>AACR<span lang=\"ZH-CN\">\uff09\u5e74\u4f1a\u4e0a\u4ee5\u4e24\u5f20\u7535\u5b50\u6d77\u62a5\u7684\u5f62\u5f0f\u5448\u73b0\u3002<\/span><\/p><p>KRAS G12C<span lang=\"ZH-CN\">\u7a81\u53d8\u662f\u4e00\u79cd\u81f4\u764c\u9a71\u52a8\u56e0\u7d20\uff0c\u53d1\u751f\u5728\u5927\u7ea6<\/span>15%<span lang=\"ZH-CN\">\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08<\/span>NSCLC<span lang=\"ZH-CN\">\uff09\uff0c<\/span>3%<span lang=\"ZH-CN\">\u7684\u7ed3\u76f4\u80a0\u764c\uff08<\/span>CRC<span lang=\"ZH-CN\">\uff09\u548c\u7ea6<\/span>1%<span lang=\"ZH-CN\">\u7684\u5176\u4ed6\u5b9e\u4f53\u7624\u4e2d\u3002<\/span>D-1553<span lang=\"ZH-CN\">\u662f\u7531\u76ca\u65b9\u751f\u7269\u81ea\u4e3b\u5f00\u53d1\u7684\u4e00\u6b3e\u65b0\u578b\uff0c\u9ad8\u6548\u4e14\u53e3\u670d\u7684<\/span>KRAS G12C<span lang=\"ZH-CN\">\u6291\u5236\u5242\u3002\u5728\u4e00\u9879\u9488\u5bf9\u643a\u5e26<\/span>KRAS G12C<span lang=\"ZH-CN\">\u7a81\u53d8\u7684\u665a\u671f\u6216\u8f6c\u79fb\u6027\u5b9e\u4f53\u7624\u60a3\u8005\u7684\u56fd\u9645\u591a\u4e2d\u5fc3\u4e00\u671f\u7814\u7a76\u4e2d\uff0c<\/span>D-1553<span lang=\"ZH-CN\">\u5728<\/span>22<span lang=\"ZH-CN\">\u4f8b\u60a3\u8005\u4e2d\u8010\u53d7\u6027\u826f\u597d\uff0c\u6ca1\u6709\u4efb\u4f55\u5242\u91cf\u9650\u5236\u6027\u6bd2\u6027\u3002\u5728<\/span>21<span lang=\"ZH-CN\">\u4f8b\u53ef\u8bc4\u4f30\u7684\u60a3\u8005\u4e2d\uff0c\u89c2\u5bdf\u5230<\/span>19.0%<span lang=\"ZH-CN\">\u786e\u8ba4\u7684\u80bf\u7624\u5ba2\u89c2\u7f13\u89e3\u7387\uff0c\u8fbe\u5230\u4e86<\/span>85.7%<span lang=\"ZH-CN\">\u7684\u75be\u75c5\u63a7\u5236\u7387\u3002\u5728\u5242\u91cf\u6c34\u5e73\u4f4e\u81f3\u6bcf\u5929<\/span>300mg<span lang=\"ZH-CN\">\u65f6\u5df2\u89c2\u5bdf\u5230\u80bf\u7624\u7f13\u89e3\u3002\u5728\u53e6\u4e00\u9879\u7531\u4e0a\u6d77\u80f8\u79d1\u533b\u9662\u9646\u821c\u6559\u6388\u4e3a\u4e3b\u8981\u7814\u7a76\u8005\uff0c\u9488\u5bf9\u643a\u5e26<\/span>KRAS G12C<span lang=\"ZH-CN\">\u7a81\u53d8\u7684\u975e\u5c0f\u7ec6\u80de\u80ba\u764c\uff08<\/span>NSCLC<span lang=\"ZH-CN\">\uff09\u60a3\u8005\u7684\u7814\u7a76\u5206\u6790\u4e2d\u5305\u62ec\u4e86<\/span>59<span lang=\"ZH-CN\">\u4f8b\u60a3\u8005\uff0c\u5176\u4e2d<\/span>52<span lang=\"ZH-CN\">\u4f8b\u4e3a\u53ef\u8bc4\u4f30\u60a3\u8005\uff0c\u80bf\u7624\u5ba2\u89c2\u7f13\u89e3\u7387\u8fbe\u5230<\/span>40.4%<span lang=\"ZH-CN\">\uff0c\u75be\u75c5\u63a7\u5236\u7387\u9ad8\u8fbe<\/span>90.4%<span lang=\"ZH-CN\">\u3002\u8fd9\u4e9b\u60a3\u8005\u5747\u4e3a\u665a\u671f\u6216\u8f6c\u79fb\u6027\u764c\u75c7\u60a3\u8005\uff0c\u5927\u591a\u6570\u5df2\u7ecf\u63a5\u53d7\u4e86\u4e8c\u7ebf\u6216\u4e8c\u7ebf\u4ee5\u4e0a\u7684\u7cfb\u7edf\u6027\u6297\u764c\u836f\u7269\u6cbb\u7597\u3002<\/span><\/p><p><span lang=\"ZH-CN\">\u76ca\u65b9\u751f\u7269\u603b\u7ecf\u7406\u738b\u8000\u6797\u8868\u793a\uff0c<\/span>&#8220;<span lang=\"ZH-CN\">\u6211\u4eec\u975e\u5e38\u9ad8\u5174\u5728<\/span>2022<span lang=\"ZH-CN\">\u5e74<\/span>AACR<span lang=\"ZH-CN\">\u5e74\u4f1a\u4e0a\u62a5\u544a<\/span>D-1553<span lang=\"ZH-CN\">\u7684\u4e34\u5e8a\u6570\u636e\u3002\u6211\u4eec\u7684\u4e34\u5e8a\u4ea7\u54c1\u7ba1\u7ebf\u6db5\u76d6\u764c\u75c7\u548c\u5176\u4ed6\u91cd\u5927\u75be\u75c5\u7684\u6cbb\u7597\u9886\u57df\uff0c<\/span>D-1553<span lang=\"ZH-CN\">\u662f\u5176\u4e2d\u7684\u5173\u952e\u4ea7\u54c1\u3002\u636e\u6211\u4eec\u6240\u77e5\uff0c\u8fd9\u6b21\u62a5\u544a\u4e2d\u5305\u62ec\u7684\u60a3\u8005\u4f8b\u6570\u662f\u76ee\u524d\u516c\u5f00\u62a5\u9053\u7684\u7531\u56fd\u5185\u836f\u4f01\u81ea\u4e3b\u5f00\u53d1\u7684<\/span>KRAS G12C<span lang=\"ZH-CN\">\u6291\u5236\u5242\u6cbb\u7597\u60a3\u8005\u4eba\u6570\u6700\u591a\u7684\u3002\u6211\u4eec\u5c06\u81f4\u529b\u4e8e\u4e0d\u65ad\u63a8\u8fdb\u8fd9\u6b3e\u836f\u7269\u7684\u4e34\u5e8a\u7814\u7a76\uff0c\u8fdb\u4e00\u6b65\u8bc4\u4f30\u5176\u5355\u836f\u548c\u4e0e\u5176\u4ed6\u836f\u7269\u8054\u7528\u5728\u764c\u75c7\u60a3\u8005\u4e2d\u7684\u6709\u6548\u6027\uff0c\u5e76\u671f\u671b\u672a\u6765\u5e26\u7ed9<\/span>KRAS G12C<span lang=\"ZH-CN\">\u7a81\u53d8\u7684\u764c\u75c7\u60a3\u8005\u66f4\u591a\u7684\u6cbb\u7597\u9009\u62e9\u3002<\/span>&#8220;<\/p><p>\u6d88\u606f\u6765\u6e90\uff1a<a href=\"https:\/\/www.prnasia.com\/story\/357654-1.shtml?utm_source=cleartime-customer&amp;utm_medium=email\">\u7f8e\u901a\u793e<\/a><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>\u4e0a\u6d772022\u5e744\u670811\u65e5 \/\u7f8e\u901a\u793e\/ &#8212; \u76ca\u65b9\u751f\u7269\uff0c\u4e00\u5bb6\u4f4d\u4e8e\u4e0a\u6d77\u5f20\u6c5f\u7684\u4e34\u5e8a\u9636\u6bb5\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u8fd1\u65e5\u9996&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"footnotes":""},"categories":[],"tags":[],"class_list":["post-5039","post","type-post","status-publish","format-standard","hentry"],"_links":{"self":[{"href":"https:\/\/lsjylc.com\/wp-json\/wp\/v2\/posts\/5039"}],"collection":[{"href":"https:\/\/lsjylc.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lsjylc.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lsjylc.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/lsjylc.com\/wp-json\/wp\/v2\/comments?post=5039"}],"version-history":[{"count":66,"href":"https:\/\/lsjylc.com\/wp-json\/wp\/v2\/posts\/5039\/revisions"}],"predecessor-version":[{"id":5158,"href":"https:\/\/lsjylc.com\/wp-json\/wp\/v2\/posts\/5039\/revisions\/5158"}],"wp:attachment":[{"href":"https:\/\/lsjylc.com\/wp-json\/wp\/v2\/media?parent=5039"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lsjylc.com\/wp-json\/wp\/v2\/categories?post=5039"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lsjylc.com\/wp-json\/wp\/v2\/tags?post=5039"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}